4-bromobut-1-ene

GHS

General Information

Implementation:

EU

Type of classification:

self-classification

Remarks:

This substance is currently listed on the substances list published by ECHA of those whose met REACH Annex III criteria:

 

# Suspected carcinogen: The Toolbox profiler Carcinogenicity (genotox and nongenotox) alerts by ISS gives an alert for carcinogenicity; ISS Carcinogenicity model in VEGA (Q)SAR platform predicts that the chemical is Carcinogen (moderate reliability)

# Suspected hazardous to the aquatic environment: Fathead Minnow toxicity model (EPA) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 57.92 mg/L (good reliability); Fish toxicity classification (SarPy/IRFMN) model in VEGA (Q)SAR platform predicts that the chemical is Toxic-3 (between 10 and 100 mg/l) (good reliability); Fish Acute Toxicity model (KNN/Read-Across) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 27.59 mg/L (moderate reliability);The Danish QSAR database contains information indicating that the substance has a 96h LC50 to fish of 38.4 mg/L; The Danish QSAR database contains information indicating that the substance has a 48h EC50 to Daphnia of 22.86 mg/L; The Danish QSAR database contains information indicating that the substance has a 96h EC50 to green algae of 20.71 mg/L

# Suspected mutagen: The Toolbox profiler in vitro mutagenicity (Ames test) alerts by ISS gives an alert for mutagenicity; CAESAR Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (moderate reliability); ISS Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (moderate reliability); KNN Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (EXPERIMENTAL value); SARPY Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (moderate reliability)

# Suspected skin irritant: The Danish QSAR database contains information indicating that the substance is predicted as skin irritant

 

The Annex III inventory is an advisory list, there are not detailed information about the used model and the predictions do not follow OECD principles. Therefore, the above data can only be used as screening information, but they are not to be considered relevant for the classification and labelling.

Related composition

Related composition:

4-bromobut-1-ene Composition

Classification

Physical hazards

Explosives

Reason for no classification:

data lacking

Flammable gases and chemically unstable gases

Reason for no classification:

data conclusive but not sufficient for classification

Aerosols

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

hazard class not assessed

Oxidising gases

Reason for no classification:

data conclusive but not sufficient for classification

Gases under pressure

Reason for no classification:

data conclusive but not sufficient for classification

Flammable liquids

Hazard category:

Flam. Liquid 2

Hazard statement:

H225: Highly flammable liquid and vapour.

Flammable solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-reactive substances and mixtures

Reason for no classification:

data lacking

Pyrophoric liquids

Reason for no classification:

data lacking

Pyrophoric solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-heating substances and mixtures

Reason for no classification:

data lacking

Substances and mixtures which in contact with water emit flammable gases

Reason for no classification:

data lacking

Oxidising liquids

Reason for no classification:

data lacking

Oxidising solids

Reason for no classification:

data conclusive but not sufficient for classification

Organic peroxides

Reason for no classification:

data conclusive but not sufficient for classification

Corrosive to metals

Reason for no classification:

data lacking

Desensitized explosives

Reason for no classification:

data lacking

Health hazards

Acute toxicity - oral

Reason for no classification:

data lacking

Acute toxicity - dermal

Reason for no classification:

data lacking

Acute toxicity - inhalation

Reason for no classification:

data lacking

Skin corrosion / irritation

Reason for no classification:

data lacking

Serious eye damage / eye irritation

Hazard category:

Eye Irrit. 2

Hazard statement:

H319: Causes serious eye irritation.

Respiratory sensitisation

Hazard category:

Resp. Sens. 1

Hazard statement:

H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Skin sensitisation

Reason for no classification:

data lacking

Aspiration hazard

Reason for no classification:

data lacking

Reproductive toxicity

Reason for no classification:

data lacking

Effects on or via lactation

Reason for no classification:

data lacking

Germ cell mutagenicity

Reason for no classification:

data lacking

Carcinogenicity

Reason for no classification:

data lacking

1. Specific target organ toxicity - single (STOT-SE)

Hazard category:

STOT Single Exp. 3

Hazard statement:

H335: May cause respiratory irritation.

Affected organs:

other: Respiratory Tract

Route of exposure:

inhalation

1. Specific target organ toxicity - repeated (STOT-RE)

Reason for no classification:

data lacking

Environmental hazards

Hazardous to the aquatic environment (acute / short-term)

Reason for no classification:

data lacking

Hazardous to the aquatic environment (long-term)

Reason for no classification:

data lacking

Hazardous to the ozone layer

Reason for no classification:

data lacking

Labelling

Signal word:

Danger

Hazard pictogram

GHS02: flame

GHS08: health hazard

GHS07: exclamation mark

Hazard statements

H225: Highly flammable liquid and vapour.

H319: Causes serious eye irritation.

H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.

H335: May cause respiratory irritation.