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EC number: 252-907-8 | CAS number: 36196-44-8
Endpoint summary
Administrative data
Description of key information
Based on read across from a structurally related category of compounds, TEMPIC is considered to be a strong sensitizer (Skin Sens 1A)
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- see attached category justification
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Parameter:
- EC3
- Value:
- > 2
- Test group / Remarks:
- read across
- Remarks on result:
- positive indication of skin sensitisation based on QSAR/QSPR prediction
- Parameter:
- SI
- Value:
- 4.13
- Test group / Remarks:
- 30% CaTG
- Parameter:
- SI
- Value:
- 4.83
- Test group / Remarks:
- 25% KTG
- Parameter:
- SI
- Value:
- 5.89
- Test group / Remarks:
- 25% MeaTG
- Parameter:
- SI
- Value:
- 6.7
- Test group / Remarks:
- 10% NaTG
- Parameter:
- SI
- Value:
- 17
- Test group / Remarks:
- 8% ATG
- Interpretation of results:
- Category 1A (indication of significant skin sensitising potential) based on GHS criteria
- Conclusions:
- Based on the category hypothesis and the presence of three thiol groups, TEMPIC should be classified as Skin Sens 1A.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the category hypothesis and the presence of three thiol groups, TEMPIC should be classified as Skin Sens 1A.
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