Reaction mass of bisisopropyl peroxydicarbonate and bis-sec-butyl peroxydicarbonate and isopropyl-secbutylperoxydicarbonate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1967

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

No CoA, pre-GLP, only males, limited information on animals and conditions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1967

Report date:

1967

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Remarks:

performed pre-GLP

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Bis-sec-butyl peroxydicarbonate

EC Number:

243-424-3

EC Name:

Bis-sec-butyl peroxydicarbonate

Cas Number:

19910-65-7

Molecular formula:

C10H18O6

IUPAC Name:

2,2'-[dioxybis(carbonyloxy)]dibutane

additive 1

Reference substance name:

Naphtha (petroleum), hydrotreated heavy

EC Number:

265-150-3

EC Name:

Naphtha (petroleum), hydrotreated heavy

Cas Number:

64742-48-9

Molecular formula:

UVCB

IUPAC Name:

Naphtha (petroleum), hydrotreated heavy

Test material form:

liquid

Details on test material:

Clear liquid

Test animals

Species:

rat

Strain:

other: Charles River CD

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: no data
- Females (if applicable) nulliparous and non-pregnant: not applicable
- Age at study initiation: no data
- Weight at study initiation: 151-186 grams
- Fasting period before study: yes
- Housing: metal cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data

IN-LIFE DATES: From: To: no data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: odorless mineral spirits

Details on oral exposure:

VEHICLE: odorless mineral spirits

MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg

DOSAGE PREPARATION (if unusual):
D-225 was maintained at -18C (0 Fahrenheit) until administered, at which time these were permitted to warm to a temperature of 10C (50 Fahrenheit) prior to dosing. The equipment used to administer these compounds (syringes, needles, beakers and diluent) were chilled to 10C (50 Fahrenheit) prior to use. Immediately after administering these compounds they were destroyed in accordance with the sponsor's instructions.

Doses:

100, 215, 464, 1000, 2150, 4640 mg/kg

No. of animals per sex per dose:

5 males

Control animals:

yes

Remarks:

vehicle controls

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
- Other examinations performed: none

Statistics:

none

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

>= 4 640 mg/kg bw

Based on:

test mat.

Remarks on result:

other: no mortalities occured

Mortality:

none

Clinical signs:

other: no data

Gross pathology:

no data

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

LD50 > 4640 mg/kg bw, no mortalities

Executive summary:

LD50 > 4640 mg/kg bw, no mortalities