Quaternary ammonium compounds, C12-14-alkyl[(ethylphenyl)methyl]dimethyl, chlorides

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

short-term repeated dose toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

appearance / physical state / colour

Type of information:

other: assessed based on test material information from another study report

Adequacy of study:

key study

Study period:

2002

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Appearance based on observations from other testing endpoints conducted on this substance all at the same laboratory.

Reason / purpose for cross-reference:

reference to other study

Principles of method if other than guideline:

Appearance assessment based on the observations made during testing for other endpoints.

GLP compliance:

yes (incl. QA statement)

Physical state at 20°C and 1013 hPa:

solid

Form:

not specified

Colour:

White

Substance type:

organic

Conclusions:

The purified form of the test substance appears as white solid.

Executive summary:

The physical state and appearance of the test substance, C12-14 ADEBAC (active not specified), were visually observed during testing of other endpoints. The purified form of the test substance appears as white solid (Sydeny, 2002).

Cross-reference 2

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

particle size distribution (granulometry)

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is marketed or used in a non solid or granular form

Cross-reference 3

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From November 2001 to January 2002

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

not specified

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

not specified

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: vapour pressure balance

Specific details on test material used for the study:

Lot no: MRT-2518-038
Identity: C12-14 ADEBAC
Purity: 68 % C12-alkyl compound, 32 % C14-alkyl compound
Appearance: White solid
Storage: Room temperature, desiccated

Key result

Test no.:

#1

Temp.:

ca. 25 °C

Vapour pressure:

ca. 0 Pa

Key result

Test no.:

#2

Temp.:

ca. 25 °C

Vapour pressure:

ca. 0 Pa

Key result

Test no.:

#3

Temp.:

ca. 25 °C

Vapour pressure:

ca. 0 Pa

Key result

Temp.:

ca. 25 °C

Vapour pressure:

ca. 0 Pa

Remarks on result:

other: Mean vapor pressure value

Results:

	Run 1	Run 2	Run 3
Correlation:	-0.99326	-0.97919	-0.99221
Slope:	-2891.4	-2525.2	-2797
Intercept	5.327	4.197	4.920
Vapour pressure (Pa) at 25ºC	4.26 × 10-5	5.34 × 10-5	3.46 × 10-5

Mean vapour pressure value of 4.4 × 10-5 Pa at 25ºC. The test substance appreared unchanged at the end of testing.

Conclusions:

Under study conditions, the mean vapour pressure of test susbatnce was determined to be 4.4 × 10-5 Pa at 25ºC.

Executive summary:

A study was conducted to determine the vapor pressure of the test substance, C12 -14 ADEBAC (active not specified) using a vapour pressure balance method, according to the OECD Guideline 104 and EU Method A.4, in compliance with GLP. Under study conditions, the mean vapour pressure of test substance was determined to be 4.4 × 10-5 Pa at 25ºC (Sydney, 2002).