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Description of key information

The acute oral toxicity of calcium hydride has been waived. CaH2 reacts violently or is ignited by air; reacts exothermically with water or moisture producing hydrogen and calcium hydroxide, releases flammable gases on contact with water. Due to these physico-chemical properties, CaH2 was not tested for the oral acute toxicity.

Nevertheless, CaH2 once reacted with either moisture or water, the substance produces gas (hydrogen) and calcium hydroxide. Therefore, a read-across with calcium hydroxide was also reported for this endpoint. According the existing study for oral acute toxicity made with OECD guideline N°425 on female rats with calcium dihydroxide, the LD50 is >2000 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

acute toxicity: oral
Data waiving:
study technically not feasible
Justification for data waiving:
acute toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Interpretation of results:
GHS criteria not met
In an acute oral toxicity test following OECD guideline N°425 ran with female rats with calcium dihydroxide, no deaths occurred at the limit dose of 2000 mg/kg bw. Therefore, the LD50 is >2000 mg/kg bw.

Additional information

Justification for classification or non-classification