(17alpha)-3-ethoxy-19-norpregna-3,5-dien-20-yn-17-ol

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Administrative data

Endpoint:

relative self-ignition temperature (solids)

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

self-heating substances / mixtures

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23 May 2016 - 02 May 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)

Version / remarks:

Rev. 6 (2009)

Deviations:

no

GLP compliance:

yes

Key result

Test procedure:

100 mm sample cube at 140°C

Max. temp. reached:

163

Result:

negative outcome (no effect observed)

An exothermic effect of the test substance was observed (see the figure below). During this effect the test substance reached a temperature of 163°C. According to the guideline, the test is positive when the sample temperature exceeds the oven temperature by 60°C during the 24 hour testing time. The result is therefore considered negative and no further testing is required.

After the experiment, the test item had turned into an orange brown solid residue in the cube and some test item was collected in a container that was placed below the cube. It indicated that the test item had been molten, decomposed and/or reacted during the experiment.

Interpretation of results:

other: not classified based on GHS or CLP criteria

Conclusions:

The substance is not self-heating.

Executive summary:

In a GLP study according to UN Test N.4, a negative result was obtained using a 10 cm sample cube at 140°C. From this it was concluded that Norethyl is not a self-heating substance.