Registration Dossier
Registration Dossier
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EC number: 203-026-2 | CAS number: 102-36-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented and scientifically acceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3,4-dichlorophenyl isocyanate
- EC Number:
- 203-026-2
- EC Name:
- 3,4-dichlorophenyl isocyanate
- Cas Number:
- 102-36-3
- Molecular formula:
- C7H3Cl2NO
- IUPAC Name:
- 1,2-dichloro-4-isocyanatobenzene
- Details on test material:
- purity: 99.94%
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 1 h, 24 h, 48 h, 72 h and 7 d after application
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Remarks:
- chemosis+redness
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 5.8
- Max. score:
- 7
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.77
- Max. score:
- 2
- Reversibility:
- fully reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.44
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Other effects:
- 24 to 72 hours white, viscous discharge
Any other information on results incl. tables
Result: 3,4-dichlorphenyl isocyanate caused serious damage to eyes
| 1 h | 24 h | 48 h | 72 h | 7 d | |||||||||||
| animal # | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 |
| chemosis | 2 | 3 | 2 | 3 | 4 | 4 | 2 | 3 | 3 | 2 | 3 | 3 | 0 | 2 | 1 |
| conjunctivae | 2 | 2 | 2 | 3 | 3 | 3 | 3 | 3 | 3 | 2 | 3 | 3 | 0 | 2 | 1 |
| iris | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
| cornea | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 2 | 0 | 3 | 2 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- The single apllication of the test item caused serious damage to the rabbit eye.
- Executive summary:
- method: single application of 0.1 g 3,4 -dichlorophenyl isocyanate into the conjunctival sac of 3 rabbits
- result: substance is irritating to the eye (risk of serious damage to eyes)
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