Registration Dossier
Registration Dossier
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EC number: 931-082-4 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: expert statement
- Adequacy of study:
- key study
Data source
Materials and methods
Test material
- Reference substance name:
- Renewable hydrocarbons (kerosene type fraction)
- EC Number:
- 931-082-4
- Cas Number:
- 2252265-89-5
- Molecular formula:
- >= 142.0 — <= 240.0
- IUPAC Name:
- Renewable hydrocarbons (kerosene type fraction)
- Test material form:
- liquid
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The toxicokinetics behaviour derived from available substance data might make further testing unnecessary in terms of predictability of other properties. In accordance with this approach (specified in “Guidance on Information Requirements and Chemical Safety Assessment”, Chapter R7c, Section R7.12.2), the report of Illing (unpublished report, 2006) can be taken into account and allows a qualitative judgement of the toxicokinetic properties of the test substance: Hydrocarbons are absorbed through the lung and the gastro-intestinal tract. They are widely distributed and excreted in urine or in exhaled air, depending on volatility. They are metabolised by ¿- or ¿-1 oxidation to the alcohol and then to the fatty acid. Fatty acids derived from hydrocarbons are likely to enter intermediary metabolism (including ß-oxidation) and be excreted in bile urine and exhaled air (as carbon dioxide) (Illing 2006). In addition 'Kerosine (Fischer-Tropsch), full range, C8-16 - branched and linear' has a measured log Kow of >6.5 and chemicals with log Kow >5 can pass through the stratum corneum but is limited by low water solubility in their ability to enter the bloodstream. However the irritating /defatting effects are likely to enhance dermal penetration.
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