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Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Version / remarks:
Adopted: 13 April 2004
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-[ethylenebis(oxymethylene)]bisoxirane
EC Number:
218-746-2
EC Name:
2,2'-[ethylenebis(oxymethylene)]bisoxirane
Cas Number:
2224-15-9
Molecular formula:
C8H14O4
IUPAC Name:
2,2'-[ethylenebis(oxymethylene)]bisoxirane
Test material form:
liquid
Radiolabelling:
no

Study design

Analytical monitoring:
yes
Buffers:
- pH: 4.0
- Composition of buffer: 4.0 mL of 0.1 N NaOH and 500 mL of 0.1 M Potassium biphthalate were added to water and made up to 1,000 mL
- pH: 7.0
- Composition of buffer: 296.3 mL of 0.1 N NaOH and 500 mL of 0.1 M Monopotassium phosphate were added to water and made up to 1,000 mL
- pH: 9.0
- Composition of buffer: 213.0 mL of 0.1 N NaOH and 500 mL of 0.1 M Boric acid in 0.1 M KCl were added to water and made up to 1,000 mL
Positive controls:
no
Negative controls:
no

Results and discussion

Transformation products:
not measured
Total recovery of test substance (in %)open allclose all
% Recovery:
105.41
St. dev.:
2
pH:
4
% Recovery:
99.5
St. dev.:
0.7
pH:
7
% Recovery:
102.6
St. dev.:
1.1
pH:
9
Dissipation DT50 of parent compoundopen allclose all
pH:
4
Temp.:
15 °C
DT50:
19.8 d
pH:
4
Temp.:
25 °C
DT50:
8.7 d
pH:
4
Temp.:
50 °C
DT50:
0.4 d
pH:
7
Temp.:
15 °C
DT50:
33 d
pH:
7
Temp.:
25 °C
DT50:
14.1 d
pH:
7
Temp.:
50 °C
DT50:
0.6 d
pH:
9
Temp.:
15 °C
DT50:
57.8 d
pH:
9
Temp.:
25 °C
DT50:
21.7 d
pH:
9
Temp.:
50 °C
DT50:
1 d

Applicant's summary and conclusion

Executive summary:

At preliminary test (Tier I), the percent hydrolysis of 2,2’-[ethylenebis(oxymethylene)] bisoxirane were 100% at pH 4.0 7.0 and 9.0, respectively, indicating that test item was unstable item at each buffer solution. Therefore, Tier II phase was conducted at three different pH conditions.

At hydrolysis test (Tier II), the values of half-life (t1/2) for 2,2’[ethylenebis(oxymethylene)] bisoxirane were 19.8, 8.7 and 0.4 days at 15, 25 and 50˚С for pH 4.0, respectively. For pH 7.0, the corresponding values were 33.0, 14.1 and 0.6 days, respectively. And for pH 9.0, the corresponding values were 57.8, 21.7 and 1.0 days, respectively. The values of half-life (t1/2) calculated using Arrhenius equation were 8.9, 14.3 and 23.7 days at 20˚С for pH 4.0, 7.0 and 9.0, respectively.

Based on these results, 2,2’-[ethylenebis(oxymethylene)] bisoxirane was considered hydrolytically unstable at pH 4.0, 7.0 and 9.0.