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Diss Factsheets

Physical & Chemical properties

Particle size distribution (Granulometry)

Administrative data

Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May 2, 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
Deviations:
no
GLP compliance:
not specified
Type of method:
Laser scattering/diffraction
Type of distribution:
other: Mie scattering theory

Test material

Constituent 1
Chemical structure
Reference substance name:
(1R,2R)-1-amino-2-difluoromethyl)-N- (1-methylcyclopropylsulfonyl)cyclo propanecarboxyamide hydrochloride
EC Number:
943-460-6
Cas Number:
1360828-80-3
Molecular formula:
C9H15CIF2N203S
IUPAC Name:
(1R,2R)-1-amino-2-difluoromethyl)-N- (1-methylcyclopropylsulfonyl)cyclo propanecarboxyamide hydrochloride
Test material form:
solid: particulate/powder
Details on test material:
White solid

Results and discussion

Particle sizeopen allclose all
Key result
Percentile:
D10
Mean:
10.85 µm
St. dev.:
1.79
Key result
Percentile:
D50
Mean:
52.33 µm
St. dev.:
2.53
Key result
Percentile:
D90
Mean:
217.4 µm
St. dev.:
0.24

Any other information on results incl. tables

  Table 2. The Particle Size Distribution Test Results of Difluorosulfonamide HCl
 Test Items  Test #1  Test #2  Test #3  Average (um)  RSD%
 D50 (um) 53.55   52.52  50.92  52.33  2.53
D10 (um)   10.95  10.98  10.63  10.85  1.79
 D90 (um)  217.0  217.2  218.0  217.4  0.24

Applicant's summary and conclusion

Conclusions:
The particle size distribution of Difluorosulfonamide HCl was tested for three times from preparing the test suspension under the same conditions. Based on the testing results, the average D50 was 52.33 um with RSD = 2.53% (n=3), the average D10 was 10.85 um with RSD = 1.79% (n=3), and the average D90 was 217.4 um with RSD = 0.24% (n=3).