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Description of key information

LOAEL= 94.7 mg/kg bw/day (QSAR prediction).

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Link to relevant study records
Reference
Endpoint:
short-term repeated dose toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Guideline:
other: REACH Guidance on QSARs R.6
Specific details on test material used for the study:
SMILES: OCC{P-}(O)C{P-}(O)C{P+}(O)C{P-}(O)C(=O)O{-}.[Cu]{+}
Key result
Dose descriptor:
LOAEL
Effect level:
94.7 mg/kg bw/day (nominal)
Based on:
not specified
Basis for effect level:
other: not specified
Key result
Critical effects observed:
not specified
Conclusions:
LOAEL= 94.7 mg/kg bw/day. According to this value and the table 3.9.3. of the CLP Regulation, classification STOT RE-2 is applicable.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LOAEL
94.7 mg/kg bw/day
Quality of whole database:
Toxicity of the target chemical (94.7 mg/kg bw/day (nominal)) is predicted by QSAR "Modelo QSAR 180404 LOAEL Gluconato". The target chemical FALLS within applicability domain of the prediction. Reliability 2.

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: inhalation - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

LOAEL= 94.7 mg/kg bw/day. According to this value and the table 3.9.3. of the CLP Regulation, classification STOT RE-2 is applicable.