Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
28 Nov 2017 - 11 Jan 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
The maximum difference was > 15%. Nevertheless, results of a repeat study were
accepted.
Evaluation: The water solubility determination was repeated using laboratory glass ware
only, as plastic surfaces might have caused adsorption in a first study. During the repeat
study, the maximum difference was again > 15% considering results of all three
timepoints. The 24 and the 72 h timepoint, however, were reasonably close to each other.
Additionally, the 72 h timpoints of both water solubility studies were very similar to each
other. The data set of the second study showed that the equilibrium water solubility
concentration was reached. Therefore, results were accepted. The average of all values
in the second study (i.e. 119 mg/L) was considered to reflect the water solubility of the
test item.
Deviations:
yes
Remarks:
None of the deviations were considered to have impacted the overall integrity of the study or the interpretation of the study results and conclusions.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
The maximum difference was > 15%. Nevertheless, results of a repeat study were
accepted.
Evaluation: The water solubility determination was repeated using laboratory glass ware
only, as plastic surfaces might have caused adsorption in a first study. During the repeat
study, the maximum difference was again > 15% considering results of all three
timepoints. The 24 and the 72 h timepoint, however, were reasonably close to each other.
Additionally, the 72 h timpoints of both water solubility studies were very similar to each
other. The data set of the second study showed that the equilibrium water solubility
concentration was reached. Therefore, results were accepted. The average of all values
in the second study (i.e. 119 mg/L) was considered to reflect the water solubility of the
test item.
Deviations:
yes
Remarks:
None of the deviations were considered to have impacted the overall integrity of the study or the interpretation of the study results and conclusions.
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methoxy-2-methylheptane
EC Number:
816-311-7
Cas Number:
76589-16-7
Molecular formula:
C9H20O
IUPAC Name:
2-methoxy-2-methylheptane
Test material form:
liquid

Results and discussion

Water solubility
Key result
Water solubility:
119 mg/L
Conc. based on:
test mat.
Incubation duration:
72 h
Temp.:
20 °C
pH:
>= 6.1 - <= 7.6
Details on results:
See attachment.

Applicant's summary and conclusion

Conclusions:
The slow-stirring flask method was applied for the determination of the water solubility of the test substance.
The water solubility of the test item at 20°C was 119 mg/L.