Registration Dossier
Registration Dossier
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EC number: 609-105-1 | CAS number: 35249-62-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)
- Deviations:
- yes
- Remarks:
- The following deviation occurred: • At the time of signing the study plan, the only test item information included was the identification CYABROMETHO. Additional test item information was subsequently available, however, a study plan amendment incorporati
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile
- EC Number:
- 609-105-1
- Cas Number:
- 35249-62-8
- Molecular formula:
- C11H12BrNO2
- IUPAC Name:
- 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile
- Test material form:
- solid
Constituent 1
Results and discussion
Effect concentrations
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 27 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- growth rate
- Remarks on result:
- other: Analysis of the test preparations at 0 hours showed measured test concentrations to range from 5.5 to 89 mg/L. There was no significant change in the measured concentrations at 72 hours and so the results are based on 0-Hour measured test concentrations o
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Analysis of the test preparations at 0 hours showed measured test concentrations to range from 5.5 to 89 mg/L. There was no significant change in the measured concentrations at 72 hours and so the results are based on 0-Hour measured test concentrations only.
The No Observed Effect Concentration was 5.5 mg/L.
The effect of the test item on the growth of Pseudokirchneriella subcapitata has been investigated and gave EC50 27 mg/L.
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