Oct-2-ene

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

Not reported

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: This study is classified as not assignable because the study is not GLP compliant and concentrations tested are not provided.

Justification for type of information:

A discussion and report on the read across strategy is given as an attachment in Section 13.

Cross-reference

Reason / purpose for cross-reference:

read-across: supporting information

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1967

Report date:

1967

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

Study was performed prior to adoption of the test guideline specified.

Principles of method if other than guideline:

The study was conducted according to the Federal Hazardous Substance Labelling Act (FHSLA).

GLP compliance:

no

Test type:

other: acute vapour inhalation screening

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Dec-1-ene

EC Number:

212-819-2

EC Name:

Dec-1-ene

Cas Number:

872-05-9

Molecular formula:

C10H20

IUPAC Name:

dec-1-ene

Details on test material:

- Name of test material (as cited in study report): Decene-1
- Substance type: C10 alpha olefin

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

other: Air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Glass cylinder chamber
- Exposure chamber volume: Approximately 20 litres
- Source and rate of air: Source not provided; air introduced at a rate of 2 L/min

TEST ATMOSPHERE
- Brief description of analytical method used: Test material concentrations were calculated based on bubbler weight loss and amount of air passed through the bubbler.

VEHICLE
- Composition of vehicle (if applicable): Air

Analytical verification of test atmosphere concentrations:

yes

Remarks:

Theoretical chamber concentrations were calculated on the basis of bubbler weight loss and amount of air passed through the bubbler.

Duration of exposure:

ca. 1 h

Concentrations:

Not provided

No. of animals per sex per dose:

Dosing range not provided; 10 male rats were exposed to 1-decene

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animas were observed periodically, but detailed Information not provided
- Necropsy of survivors performed: yes
- Other examinations performed: Necropsied animals were examined for gross pathology; specific details on gross pathology not provided

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

other: An LC50 was not calcuated

Remarks on result:

other: Exposed rats exhibited sleepy, slightly dazed appearance 45 minutes post-exposure. Recovery was observed immediately after exposure. Autopsy revealed no gross pathological changes. No mortalities or significant weight changes were observed post exposure.

Gross pathology:

.

Applicant's summary and conclusion

Interpretation of results:

other: Not classified

Remarks:

An acute LC50 was not reported based on the study conducted. Criteria used for interpretation of results: EU

Conclusions:

The author did not provide any conclusive statements with regards to the potential toxicity of 1-decene. An acute LC50 was not reported based on the study conducted.

Executive summary:

In an acute vapour inhalation screening study, rats were exposed to saturated vapours of 1-decene for 1 hour. Exposed rats showed minimal effects characterized by sleepy, slightly dazed appearance that began 45 minutes post-exposure. Recovery was observed to be immediate upon removal from the exposure chamber. Autopsy conducted at the end of the 14-day observation period revealed no gross pathological changes. In addition, no mortalities or significant weight changes were observed post exposure. The study author did not provide any information or conclusions regarding the determination of an LC₅₀ for 1-decene.

This study received a Klimisch rating of 4 and is classified as not assignable because the study is not GLP compliant and the concentrations tested are not provided.

This study was selected as a supporting study because it received a lower Klimisch score than the selected read-across studies; however, this study contains relevant and useful data, allowing it to qualify as a supporting study.