Registration Dossier
Registration Dossier
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EC number: 258-007-1 | CAS number: 52558-73-3
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
ErC50 (72 h) = 13.47 mg/L (nominal, OECD 201, P. subcapitata); read across
ErC10 (72 h) = 4.448 mg/L (nominal, OECD 201, P. subcapitata); read-across
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 13.47 mg/L
- EC10 or NOEC for freshwater algae:
- 4.448 mg/L
Additional information
No studies investigating the short-term toxicity to aquatic algae are available for N-(1-oxotetradecyl)sarcosine (CAS 52558-73-3). Therefore, in accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance Sodium N-methyl-N-(1-oxotetradecyl)aminoacetate (CAS 30364-51-3), the respective sodium salt, was conducted.
This read-across approach is in compliance with Annex XI, 1.5, of Regulation (EC) No 1907/2006. The chemical properties of the target and source substance are similar due to the structural similarities, i.e., sarcosine head group and the hydrocarbon tail. In addition, at physiological pH values (above 6) the target substance is expected to be in the anionic form, as are the source substance. As a result, the chemistry of the target and source substance, in solution (above pH 6), are expected to be similar. Thus, the source substance is considered suitable representative for the assessment of the aquatic toxicity of the target substance. A detailed analogue approach justification is provided in the technical dossier (see IUCLID Section 13).
The study conducted with the source substance Sodium N-methyl-N-(1-oxotetradecyl)aminoacetate (CAS 30364-51-3) was investigated in one study according to OECD Guideline 201 and GLP using the freshwater algae Pseudokirchneriella subcapitata. The first main test did not meet the validity criteria as the coefficient of variation of the replicates for the control was > 7% for the 72-hour test period. Therefore, this main test was repeated. All validity criteria for the second main test were met. The algae cells were exposed for a period of 72 h to nominal test concentrations of 0.32, 1.0, 3.2, 10.0, and 32.0 mg/L. No analytical measurement was conducted. After72 h inhibition of growth was observed in the two highest test concentrations (10 and 32 mg/L) resulting in an ErC50 (72 h) of 13.47 mg/L (nominal) and an ErC10 (72 h) of 4.448 mg/L (nominal).
Based on the available results from a structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5), which is characterized by a similar chemistry, it can be concluded that the target substance N-(1-oxotetradecyl)sarcosine (CAS 52558-73-3) will exhibit comparable effects on aquatic algae.
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