Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 288-309-9 | CAS number: 85711-49-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,3-dihydroxypropyl oleate
- EC Number:
- 203-827-7
- EC Name:
- 2,3-dihydroxypropyl oleate
- Cas Number:
- 111-03-5
- Molecular formula:
- C21H40O4
- IUPAC Name:
- 2,3-dihydroxypropyl (9Z)-octadec-9-enoate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Taiyo Kagaku; 401160
- Purity test date: 99.93 %
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Remarks:
- Crj:CD(SD)IGS
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 123 - 125 g
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 +/-3°C
- Humidity (%): 50 +/- 20%
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred.
- Clinical signs:
- other: There were no abnormalities in general condition in any animal.
- Gross pathology:
- There were no abnormalities in gross pathological findings in any animal.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- A single dose oral toxicity test of 2,3-dihydroxypropyl 9-cis-octadecenoate in rats allowed classification of the chemical into category 5 of the GHS regarding acute toxicity which does not result in any classification as to the CLP regulation.
There were no abnormalities in general condition, body weight or gross pathological findings in any animal.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
