Registration Dossier
Registration Dossier
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EC number: 402-480-0 | CAS number: 111850-26-1
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.12 (Mutagenicity - In Vivo Mammalian Erythrocyte Micronucleus Test)
- Version / remarks:
- Essai du micronoyau CEE B12
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- -
- EC Number:
- 402-480-0
- EC Name:
- -
- Cas Number:
- 111850-26-1
- Molecular formula:
- C24H23ClN8O11S3.xK.yNa
- IUPAC Name:
- potassium disodium 4-({4-chloro-6-[(4-sulfophenyl)amino]-1,3,5-triazin-2-yl}amino)-2-[(E)-2-[1-ethyl-6-hydroxy-4-methyl-2-oxo-5-(sulfomethyl)-1,2-dihydropyridin-3-yl]diazen-1-yl]benzene-1-sulfonate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: souris albinos
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- Eau distillée
- No. of animals per sex per dose:
- Male: 5000 mg/kg; No. of animals: 5; Sacrifice time: 20 hours
Male: 5000 mg/kg; No. of animals: 5; Sacrifice time: 44 hours
Male: 5000 mg/kg; No. of animals: 5; Sacrifice time: 68 hours
Female: 5000 mg/kg; No. of animals: 5; Sacrifice time: 20 hours
Female: 5000 mg/kg; No. of animals: 5; Sacrifice time: 44 hours
Female: 5000 mg/kg; No. of animals: 5; Sacrifice time: 68 hours
Results and discussion
- Additional information on results:
- Observations: Pas de symptome de toxicité relevé
English
No symptom of toxicity observed
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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