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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
96 hours
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Published data on key component of the substance
The substance dissociates in water under environmental conditions and an assessment of toxicity can be performed by considering the key dissociated ions present in water.
The three ions will be Manganese, sulphate and glycinate
Reason / purpose for cross-reference:
read-across: supporting information
Reason / purpose for cross-reference:
read-across source
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Principles of method if other than guideline:
Performed to US Federal standards, including animal welfare rules
GLP compliance:
not specified
Remarks:
Academic research
Specific details on test material used for the study:
Hydrated form used.
Results are adjusted to reflect anhydrous and total Mn
Analytical monitoring:
yes
Remarks:
No detail, but flow-through system calibrated and validated
Vehicle:
no
Test organisms (species):
Salmo trutta
Details on test organisms:
Brown trout
Test type:
flow-through
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
Reported as 'hard water' at over 150 mg/l Calcium carbonate
Test temperature:
Reported to be in line with Federal animal welfare (10 - 15 C required)
pH:
Not adjusted
Nominal and measured concentrations:
No details on treatment levels reported
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
ca. 198 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
Calculated based on Mn content
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
ca. 49 mg/L
Nominal / measured:
nominal
Conc. based on:
element
Remarks:
Mn
Basis for effect:
mortality (fish)
Details on results:
No direct observations included
Conclusions:
Toxicity of MnSO4 resulted in an apparent toxic effect of 49 mg/l Mn.
Note that work by the same institute on other Mn salts show similar range of toxicity to Mn suggesting that the counter ion is not critical when fully dissolved in water. However, there is apparent variation between species and hardness with greater toxicity in soft water.
Based on the toxicity of Mn, it is predicted that the LC50 of the substance is 198 mg/l

Description of key information

Toxicity of MnSO4 resulted in an apparent toxic effect of 49 mg/l Mn.
Note that work by the same institute on other Mn salts show similar range of toxicity to Mn suggesting that the counter ion is not critical when fully dissolved in water. However, there is apparent variation between species and hardness with greater toxicity in soft water.
Based on the toxicity of Mn, it is predicted that the LC50 of the substance is 198 mg/l

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Dose descriptor:
LC50
Effect concentration:
ca. 198 mg/L

Additional information