Nickel(2+) diammonium 2,2',2'',2'''-(ethane-1,2-dinitrilo)tetraacetate

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

This reports evaluates the eye irritating properties of metallic nickel and several widely used nickel(2+) salts. It collects all available information on toxicological properties of those substances, was written and reviewed by experts and thus can be seen as a reliable data source.

Data source

Reference

Reference Type:

review article or handbook

Title:

European Union Risk Assessment Report; nickel and nickel compounds

Author:

Luxembourg: Office for Official Publications of the European Communities, Rapporteur for the risk assessment of Nickel is Denmark

Year:

2008

Bibliographic source:

EU Risk Assessment Reports, #93, 2008

Materials and methods

Test guideline

Qualifier:

no guideline required

Principles of method if other than guideline:

This reports evaluates the eye irritating properties of metallic nickel and several widely used nickel salts. It collects all available information on toxicological properties of those substances, was written and reviewed by experts and thus can be seen as a reliable data source.

GLP compliance:

not specified

Test material

Test material information

1

Reference substance name:

Nickel sulphate

EC Number:

232-104-9

EC Name:

Nickel sulphate

Cas Number:

7786-81-4

Molecular formula:

H2O4S.Ni

IUPAC Name:

Nickel (II)sulphate

Specific details on test material used for the study:

The report refers to studies on metallic nickel and several metal salts, e.g. nickel sulphate.

Results and discussion

In vivo

Results

Irritation parameter:

other: evaluation of the parameters of several studies

Basis:

mean

Time point:

other: not stated

Score:

0

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The report concludes that neither nickel nor the evaluated nickel salts are eye irritating due to their chemical properties. For metallic nickel powder a mechanical eye irritation has to be considered.