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Physical & Chemical properties

Particle size distribution (Granulometry)

Administrative data

Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: CIPAC MT 187 “Particle Size Analysis by Laser Diffraction”, Handbook K, 2007
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution

Test material

Constituent 1
Chemical structure
Reference substance name:
Terephthalaldehyde
EC Number:
210-784-8
EC Name:
Terephthalaldehyde
Cas Number:
623-27-8
Molecular formula:
C8H6O2
IUPAC Name:
benzene-1,4-dicarbaldehyde
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
Batch (Lot) Number: 180401
Expiry date: 01 April 2020 (retest date)
Physical Description: Light yellow powder
Purity/Composition: 99.6%
Storage Conditions: At room temperature

Results and discussion

Mass median aerodynamic diameter:
ca. 57.2 µm
Geometric standard deviation:
ca. 2.348
Particle sizeopen allclose all
Percentile:
D10
Mean:
ca. 14.6 µm
St. dev.:
0.036
Percentile:
D50
Mean:
ca. 49.1 µm
St. dev.:
0.377
Percentile:
D90
Mean:
ca. 129 µm
St. dev.:
0.753

Any other information on results incl. tables

During the method development phase of the analysis trials were conducted using the dry

powder module (DPM) only. The results of these trials indicated that the most appropriate

test and material parameters to obtain the optimum measurements were:

Module   : DPM

Dispersant   : Air

Dispersion pressure    : 0.5 barg

Refractive index (sample) : 1.500 n

Absorption   : 0.000 AU

Analysis Model  : General Purpose

Using the identified parameters, the particle size was analysed over the range 0.01 µm to

3500 µm. The results of the formal analysis are presented in Table 9:1. In addition, a graph

of volume (%) versus Particle Diameter (µm), and full particle size distribution, is provided in

Graph 9.A (Average of 5 runs).

Table 9:1 : Full Test Results

   run 1  run 2  run 3  run 4  run 5  average  STDVP  %STDVP
 VWM  62.6  62.4  63.0  62.8  62.8  62.7  N/A  N/A
 MODE  55.0  54.9  56.0  56.1  56.0  55.6  N/A  N/A
 D10  14.6  14.7  14.7  14.6  14.7  14.6  0.0364  0.248
 D50 (MEDIAN)  48.7  48.7  49.3  49.3  49.4  49.1  0.377  0.767
 D90  128  128  129  129  129  129  0.753  0.585
 MMAD  56.7  56.8  57.5  57.5  57.6  57.2  0.393  0.7
 GSD  2.350  2.345  2.351  2.348  2.345  2.348  0.002  0.1

All particle size results are in µm

5.27 % by volume of sample was seen to be < 10.00 µm

Definitions

VWM  : volume weighted mean

d10  : 10 % of the test item is less than this particle size

d50  :  50 % of the test item is less than this particle size

d90  :  90 % of the test item is less than this particle size

GSD   : geometric standard deviation of the lognormal particle size distribution

MMAD  : mass median aerodynamic diameter

Average : calculated from the entirety of the data captured in each run and not a

  simple arithmetic mean

STDVP : standard deviation of the population

% STDVP : percentage standard deviation of the population

The coefficient of variation for d50 is less than 3 %; d10 and d90 are less than 5 %. Thus

repeatability of the characteristic particles in the size distribution is within the acceptable

limits as per the ISO 13320-1 test standard.

Applicant's summary and conclusion

Conclusions:
The MMAD of the tested sample was measured as 57.2 µm, with a volume weighted mean of 62.7 µm. The particle distribution was as follows: d10 14.6µm, d50 49.1µm and d90 129µm. The volume of sample<10µm was 5.27%.