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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

in vitro gene mutation study in bacteria
Type of genotoxicity: gene mutation
Adequacy of study:
other information

Data source

Reference Type:
other: Body responsible for the test

Materials and methods

Test guideline
according to guideline
other: Annex V B13/B14
GLP compliance:
Type of assay:
bacterial reverse mutation assay


Species / strain
Species / strain / cell type:
bacteria, other: Salmonella typhimurium TA1535, TA1537, TA98, TA100 Escherichia coli WP2 (pKM101), WP2 uvrA (pKM101)
Metabolic activation system:
Liver S9 derived from phenobarbital/Beta-naphthoflavone-induced Sprague Dawley rats
Test concentrations with justification for top dose:
Concentration range in the main test (with metabolic activation): 100 ... 5000 µg/plate
Concentration range in the main test (without metabolic activation): 100 ... 5000 µg/plate
Vehicle / solvent:
Solvent: Dried dimethylsulphoxide
Details on test system and experimental conditions:
Concentration of the test substance resulting in precipitation: 1000 µg/plate

Results and discussion

Applicant's summary and conclusion

Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation