Registration Dossier
Registration Dossier
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EC number: 203-917-6 | CAS number: 111-87-5
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Type of information:
- other: collection of data
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- other: collection of data
- Title:
- Query: Records containing the term 1-OCTANOL as displayed on http://toxnet.nlm.nih.gov on December 18, 2018.
- Author:
- Hazardous Substances Data Bank (HSDB)
- Reference Type:
- review article or handbook
- Title:
- Patty's Toxicology Volumes 1-9 5th ed.
- Author:
- Bingham, E.; Cohrssen, B.; Powell, C.H.
- Year:
- 2 001
- Bibliographic source:
- Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V6 469
Materials and methods
- GLP compliance:
- not specified
Test material
- Test material form:
- liquid
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
Results and discussion
Any other information on results incl. tables
Developmental or Reproductive Toxicity/ In an oral gavage study, pregnant female Wistar rats were dosed with 0, 130, 650, 975, or 1300 mg/kg 1-octanol during gestational days 6 through 15. Maternal toxicity occurred with a dose-related increase in severity of clinical signs, including lateral and abdominal position, unsteady gait, salivation, piloerection, nasal discharge, and pneumonia. Food consumption and body weight gain decreased slightly in all but the lowest dose group. There was no developmental toxicity.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
