Registration Dossier
Registration Dossier
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EC number: 401-310-2 | CAS number: 93912-64-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Ames method used, 4 strains.
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- -
- EC Number:
- 401-310-2
- EC Name:
- -
- Cas Number:
- 93912-64-2
- Molecular formula:
- Hill formula: C37H23N10O22S7Cl.6Na CAS formula: C37H23N10O22S7ClNa6
- IUPAC Name:
- Hexasodium 2-[8-amino-7-[[5-[[4-chloro-6-[[3-[[2-(sulfato)ethyl]sulfonyl]phenyl]amino]-1,3,5-triazin-2-yl] amino]-2 sulfonatophenyl]azo]-1-hydroxy-3,6-disulfonato-2-naphthalenyl]azo]-naphthalene-1,5-disulfonate
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: Salmonella typhimurium :TA98, TA100, TA102, TA1535 and TA1537
- Metabolic activation:
- with and without
- Metabolic activation system:
- Rat liver S-9 extract
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 200 - 7500 µg/plate
Concentration range in the main test (without metabolic activation): 200 - 7500 µg/plate - Vehicle / solvent:
- Solvent: Water
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 7500 µg/plate)
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 7500 µg/plate)
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- No indications of toxicity or increase in reversion noted.
- Remarks on result:
- other: other: preliminary test
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
with metabolic activation : -
without metabolic activation : -
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
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