Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

In groups of volunteers, prick test and intradermal tests showed that 2.5% of subjects developed a sensitization by skin contact.

There are many studies showing the ability of penicillins and cephalosporins to cause contact allergy (contact dermatitis) .

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

Many studies also show a respiratory sensitization to penicillins and cephalosporins, confirmed by appropriate tests of bronchial stimulation.A study on the intermediate most commonly used in the synthesis of cephalosporins, the 7-ACA, tends to confirm the presence of an immunological mechanism, as a result of asthma symptoms encountered in the professional field.

Justification for classification or non-classification