Vanadium oxysulphate

Long-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

fish early-life stage toxicity

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Initial mortality and vigour test of 28 days

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Justification for type of information:

This report is part of wider research, including a reproductive toxicity test on fish.
A preliminary assessment was made at 28 days, stating with week-old fry

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)

Principles of method if other than guideline:

One week old fry were exosed to different concentrations of vanadium for 28 days.
Low-dose groups were maintained for longer periods up to maturity and reproduction effects examined.

GLP compliance:

no

Specific details on test material used for the study:

Source of vanadium is described as predominantly sulphate, but oxy-sulphates and other salts will exist in the water column tested.
Results are expressed as vanadium.
Different valencies will also exist depending on pH
The report makes it clear that the vanadium form will be difficult to monitor and will change under conditions of analysis.
It is assumed that the vanadium under the test conditions would be penta-valent at the pH of the assessment

Analytical monitoring:

yes

Details on sampling:

Assessment for vanadium content

Vehicle:

no

Test organisms (species):

Jordanella floridae

Details on test organisms:

Common name 'Flagfish', chosen for short life cycle

Test type:

flow-through

Water media type:

freshwater

Limit test:

no

Total exposure duration:

28 d

Remarks on exposure duration:

Lower dose treatment groups had extended exposure period of about 100 days to examine long-term effects including reproduction

Hardness:

Average 347 mg/l CaCO3

Test temperature:

Average 25 C

pH:

Average 8.15

Dissolved oxygen:

Average 7.4 mg/l

Nominal and measured concentrations:

0.051, 0.58, 3.4, and 6.3 mg/l of vanadium, nominal
(Measured 0, 0.051, 0.58, 3.4, and 6.3 mg/l)

Reference substance (positive control):

no

Duration:

28 d

Dose descriptor:

LC10

Effect conc.:

> 0.56 mg/L

Nominal / measured:

nominal

Conc. based on:

element

Remarks:

Vanadium

Basis for effect:

mortality

Key result

Duration:

28 d

Dose descriptor:

LC10

Effect conc.:

> 1.9 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other:

Remarks:

Starting with LC10 of 0.56 for V and using molecular weight of constituent with greatest proportion of vanadium

Details on results:

There was 100% mortality at 5.6 mg/l vanadium and > 50% mortality at 3.14 mg/l.
The lower concentrations of 0, 0.056 and 5.6 had a level of 5 - 10% mortality, including 4/60 deaths in the control.

Conclusions:

It is concluded that the oxysuphate salts will be toxic at over 2 mg/l (0.56 mg/l vanadium).

Longer term exposure of 70 days showed good survival at 0.48 mg/l vanadiaum suggesting that there is no accumulative toxicity.
There was good survival, good egg production and good viablity of fry at 0.48 mg/l in the reproduction group extended to over 90 days exposure.

Description of key information

It is concluded that the oxysulphate salts will be toxic at over 2 mg/l (0.56 mg/l vanadium) and as vanadium is an essential element at low concentrations, it is not considered accumulative, suggesting that classification is not required

Longer term exposure of 70 days showed good survival at 0.48 mg/l vanadiaum suggesting that there is no accumulative toxicity.

There was good survival, good egg production and good viablity of fry at 0.48 mg/l in the reproduction group extended to over 90 days exposure.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

2 mg/L