Registration Dossier
Registration Dossier
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EC number: 250-264-8 | CAS number: 30618-84-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Significant methodological deficiencies
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- only one test concentration; 1 h exposure; 14 days observation; maximum aerosol concentration not described; particle size not measured; test material insufficiently characterised
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Mercaptoacetic acid, monoester with propane-1,2,3-triol
- EC Number:
- 250-264-8
- EC Name:
- Mercaptoacetic acid, monoester with propane-1,2,3-triol
- Cas Number:
- 30618-84-9
- Molecular formula:
- C5H10O4S
- IUPAC Name:
- 2,3-dihydroxypropyl 2-sulfanylacetate
- Test material form:
- solid - liquid: suspension
- Details on test material:
- - Name of test material (as cited in study report): Glycerol Monothioglycolate
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 1 h
- Concentrations:
- 2.04 mg/L nominal concentration
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- >= 2.04 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 1 h
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- Exposure of five male and five female Sprague-Dawley rats to aerosolized GMT at a nominal concentration of 2.04 mg/L
did not produce mortality in any animals.
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