Registration Dossier
Registration Dossier
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EC number: 232-435-9 | CAS number: 8028-89-5 The substance obtained by controlled heat treatment of food-grade carbohydrates. Food-grade acids, alkalies, and salts may be used to assist carmelization. Food-grade antifoaming agents may be used in an amount not greater than that required to produce the intended effect. Consists essentially of colloidal aggregates that are dispersible in water but only partly dispersible in alcohol-water solutions. Depending upon the particular carmelizing agent used, may have a positive or negative colloidal charge in solution.
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- no
- Type of method:
- HPLC estimation method
- Media:
- soil
Test material
- Reference substance name:
- Caramel (color)
- EC Number:
- 232-435-9
- EC Name:
- Caramel (color)
- Cas Number:
- 8028-89-5
- Molecular formula:
- C6H12OH
- IUPAC Name:
- Caramel
Constituent 1
- Radiolabelling:
- not specified
Study design
- Test temperature:
- 40°C +/- 1°C (oven temperature)
HPLC method
- Details on study design: HPLC method:
- -Reference substances: sodium nitrate, acetanilide, atrazine, linuron, fenthion, trifluralin, 4,4'-DDT
-Preparation of working solutions: see the tables below
-System: 1260 Infinity II LC : (Agilent)
-Columns: HYPERSIL CN-CPS 5μm (4.6 x 150 mm)
-Sample injection: 5 μL
-Oven temperature: column = 40°C +/- 1°C
-Mobil phase and program:
Isocratic mode
Flow : 1.25mL/min
A : 45% Ultrapure water (18.2 megaohms/cm)
B : 55% Methanol (HPLC-MS grade)
Detector: UV (190-800nm), Chromatogram analysis at 210 nm.
Results and discussion
Adsorption coefficient
- Key result
- Type:
- log Koc
- Value:
- ca. 0.432 dimensionless
Results: HPLC method
- Details on results (HPLC method):
- More details in the table below.
Repeatability:
The values of log Koc derived from individual measurements are within a range of 0.25 log unit, so within the criteria of the OECD 121 guideline.
Any other information on results incl. tables
| Test item | Quantity introduced in the column (ng) | Retention times | Log k' | Log Koc |
| Caramel Colour E150c | 570 | 3,86 | -0,0890 | 0,422* |
| Caramel Colour E150c | 570 | 3,868 | -0,0870 | 0,441* |
0,432 |
*It is important to note that there is no reference substance with a retention time below the test item retention time. The Log Pow was measured with an extrapolation of the regression.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The estimated Adsorption Coefficient (Koc) logarithm of the test item on Soil is <1.25 (about 0.432 using extrapolation of the regression).
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