Boswellia papyrifera, ext.

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

October 25 - November 07, 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

The study was conducted according to an internationally recognised method, and under GLP. The test substance is adequately characterised. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

2008

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

GLP compliance programme (inspected on 20-21 June 2017 / signed on 4 September 2017)

Type of method:

differential scanning calorimetry

Key result

Boiling pt.:

>= 160 - <= 385 °C

Atm. press.:

101.3 kPa

Results

Boiling point / boiling range:DSC measurement

Two DSC measurements in aluminium crucibles with a hole were performed. The crucibles were cooled to -50 °C and -80°C, respectively, with a rate of 1 K/min and hold at this temperature for 5 h. Afterwards followed heating with a rate of 10 K/min. Two endothermal effects followed in the temperature range of 160 – 385 °C. No further endothermal or exothermic effects were observed up to the final temperature (500 °C). The mass loss after the DSC measurements amounted to 100 %.

The onset temperature was derived from the intersection of the tangent line with the highest slope of the endothermal peak with the baseline.

The results of the DSC measurements are summarized in table below.

Table 4.3.1.-Boiling point (DSC measurement)

Ident No.	Test item / mg	Starting temperature / °C	Final test temperature / °C	Temperature range (endo-thermal) / °C	Onset  (boiling) / °C	Crucible	Observations after the measurement
38309	12.37	-50	500	160 – 280 300 – 370	209.6 321.9	Aluminium with a hole	The crucible was empty
38312	12.01	-80	500	190 – 270 310 – 385	210.6 324.6	Aluminium with a hole	The crucible was empty

Due to the broad endothermal signals for boiling the 2^ndmeasurement was not evaluated here (see figures on the experimental report).

Graphical presentations of the DSC runs are shown on the experimental report

According to the certificate of analysis the test item is UVCB substance. Thus from the results of the DSC measurements a boiling range is stated. The test item showed a multistage boiling in the temperature range of 160 – 385 °C.

Conclusions:

The boiling point of the substance was determined under experimental circumstances within the following range: (160-385 °C) using DSC method.

Executive summary:

The boiling point of the test item was measured under GLP according to OECD 103 / EU A2 guideline, by DSC.

3 runs were performed.

Two endothermal effects followed in the temperature range of 160 – 385 °C. No further endothermal or exothermic effects were observed up to the final temperature (500 °C). The mass loss after the DSC measurements amounted to 100 %. The test item showed a multistage boiling in the temperature range of 160 – 385 °C. These values are the results of two independent measurements using DSC method.

Note that these results may vary with the substance composition and should therefore be considered with caution. No observations were made which might cause doubts on the validity of the study outcome. Therefore, the result of the study is considered valid.

Description of key information

The boiling range of the substance was determined under experimental circumstances within the following range: (160 - 385 °C) using DSC method.

Additional information

A reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study. The result being expressed as a range, it cannot be retained as (single) key data.