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EC number: 948-606-2
CAS number: -
Calculation and Results of Individual Data:
Test item concentration %
Number of lymph nodes
DPM per lymph nodeb
1 = Control group
2 -4 = Test group
a = The mean value was taken from the figures BG I and BG II
b = Since the lymph nodes of the animals of a dose group were pooled,
DPM/node was determined by dividing the measured value by the number of
lymph nodes pooled.
In the study the test item Reaction mass of crystalline magnesium
silicate and crystalline silicon and synthetic amorphous silicon dioxide
formulated in PG (propylene glycol) was assessed for its possible skin
For this purpose a local lymph node assay was performed using test item
concentrations of 5, 10, and 25% (w/w). The highest concentration tested
was the highest concentration that could technically be achieved.
The animals did not show any signs of systemic toxicity or local skin
irritation during the course of the study and no cases of mortality were
In this study Stimulation Indices (S.I.) of 1.13, 1.10, and 1.14 were
determined with the test item at concentrations of 5, 10, and 25% (w/w)
in PG, respectively.
The test item Reaction mass of crystalline magnesium silicate and
crystalline silicon and synthetic amorphous silicon dioxide was not a
skin sensitiser under the test conditions of this study.
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