Registration Dossier
Registration Dossier
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EC number: 443-860-6 | CAS number: 302776-68-7
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The test on early life-stage toxicity of the test substance to embryos, larvae and young fish has been examined in a GLP guideline study according to OECD 210 with the organism Pimephales promelas in a flow through test system set-up [BASF SE 2012].
Since the test substance is sparingly soluble in water, a saturated solution of the test substance in the dilution water was prepared using a saturation column. Saturated test concentrations were monitored by concentration control analytics. The results show that the test concentrations were within ±20% of the mean measured value during the entire testing period, excluding the last week of exposure where a slight decrease in the measured test concentration was observed. However, concentrations were maintained above the geometric mean (8.8 µg/L) and were in the range of the reported water solubility (16 ± 3 µg/L) over the majority of the exposure period. Therefore, a worst-case exposure was maintained during the most critical life stages of the test fish. Thus, at test termination after 34 days, an overall NOEC >= 8.8 µg/L was determined. It can be concluded that the test substance had no observable chronic effects on Pimephales promelas up to its saturation limit in the test media and under test conditions.
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