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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-reviewed journal

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1947
Report date:
1947

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Remarks:
Date of study well before GLP requirements
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Ammonium iron(III) citrate
EC Number:
214-686-6
EC Name:
Ammonium iron(III) citrate
Cas Number:
1185-57-5
Molecular formula:
C6H8O7xH3N
IUPAC Name:
2-Hydroxypropane-1,2,3-tricarboxylate, ammonium iron (3+) salt

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
The rabbits used were of both sexes and weighed between 2 and 3 kg. They were fasted overnight and were then given by stomach tube doses of the iron compounds, graded and proportionate to their body weights. Two animals were used for each dose and at least ten animals for each substance.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
2.8g/kg
No. of animals per sex per dose:
Two animals (sex not specified per se) ten animals per substance
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 800 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be 2800 mg/kg bw,when groups of 5 male and female rabbits were treated with the given test chemical orally via gavage.