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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

An in vivo skin irritation/corrosion study is available.  The study was conducted on a single male New Zealand White rabbit according to OECD Guideline 404. The results of this single rabbit investigation following a 3-minute exposure indicated corrosive effects of acute exposure and no additional animals were exposed.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

The potential of the test substance to induce skin irritation was evaluated in rabbits according to OECD (No. 404, 17thJuly 1992) and EC (96/69/EEC, B.4, 31 July 1992) guidelines. The study was conducted in compliance with the principles of Good Laboratory Practice Regulations.

In the first instance, the test substance was applied for a period of 3 minutes and 4 hours to a single male New Zealand White rabbit. As the test substance showed corrosive properties on this first animal, the study was considered complete and the test item was not evaluated on other animals.A single dose of 0.5ml of the undiluted test substance was applied to the closely-clipped skin of one flank.

The test substance was held in contact with the skin by means of a semi-occlusive dressing. Cutaneous reaction were observed approximately 1 hour and 24 hours after removal of the dressing.

After a 3-minute or a 4-hour exposure, necrosis was noted at the application site 24  hours after removal of the dressing (day 2) The animal was then killed for ethical reasons. Under our experimental conditions, the test substance is corrosive when applied topically to rabbits.

In accordance with CLP Regulation 1272/2008, the test substance should be classified as Category 1 B corrosive substance with the signal word Danger and the hazard statement "H314: Causes severe skin burns and eye damage" associated with it. According to Directive 67/548/EEC, the test substance should be classified as Corrosive (C) and have the risk phrase "R35: Causes severe burns" associated with it.

The corrosive results obtained in rabbit dermis preclude conducting an in vivo assessment of ocular reactions. It is assumed that serious damage or ocular corrosion would occur from single exposure of the eye. This hazard is recognised in the GHS classification of H314.


Effects on skin irritation/corrosion: corrosive

Justification for classification or non-classification

In accordance with CLP Regulation 1272/2008, the test substance should be classified as Category 1 B corrosive substance with the signal word Danger and the hazard statement "H314: Causes severe skin burns and eye damage" associated with it. According to Directive 67/548/EEC, the test substance should be classifed as Corrosive (C) and have the risk phrase "R35: Causes severe burns" associated with it.

The corrosive results obtained in rabbit dermis preclude conducting an in vivo assessment of ocular reactions. It is assumed that serious damage or ocular corrosion would occur from single exposure of the eye. This hazard is recognised in the GHS classification of H314.