Registration Dossier
Registration Dossier
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EC number: 201-051-3 | CAS number: 77-71-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, and documentation / justification is limited
- Justification for type of information:
- Documentation about the justification is provided in attachment (See QMRF). The reliability assessment of the prediction is presented in the attached document (QPRF).
Data source
Reference
- Reference Type:
- other: QSAR model
- Title:
- EGA in silico platform v.1.1.5
- Year:
- 2 019
- Bibliographic source:
- Algae Classification Toxicity model (ProtoQSAR/Combase) 1.0.0
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.
Test material
- Reference substance name:
- 5,5-dimethylhydantoin
- EC Number:
- 201-051-3
- EC Name:
- 5,5-dimethylhydantoin
- Cas Number:
- 77-71-4
- Molecular formula:
- C5H8N2O2
- IUPAC Name:
- 5,5-dimethylimidazolidine-2,4-dione
Constituent 1
- Specific details on test material used for the study:
- O=C1NC(=O)C(N1)(C)C
Results and discussion
Effect concentrations
- Remarks on result:
- other: NON-Toxic
- Remarks:
- Predicte by ProtoQSAR/Combase v.1.0.0
Any other information on results incl. tables
The prediction was deemed to be not reliable on the basis of the parameters listed above. The molecule does not fall into the applicability domain of the model.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- no
- Conclusions:
- The substance was predicted to be NON-Toxic for Algae.
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