Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19th August 2019 to 23rd August 2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
July 27th 1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
30 May 2008
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
3-tert-butyl-1-(3,5-dicarboxyphenyl)-1H-pyrazol-5-aminium chloride
EC Number:
941-661-3
Molecular formula:
C15H18ClN3O4
IUPAC Name:
3-tert-butyl-1-(3,5-dicarboxyphenyl)-1H-pyrazol-5-aminium chloride
impurity 1
Reference substance name:
Unidentified impurity
IUPAC Name:
Unidentified impurity

Results and discussion

Water solubility
Key result
Water solubility:
ca. 60.1 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
18 other: mg/50ml
Incubation duration:
3 d
Temp.:
20 °C
pH:
>= 3.01 - <= 3.05

Applicant's summary and conclusion

Conclusions:
The water solubility of the test item was determined to be 60.1 mg/L with 3.3 RSD% at 20°C ± 0.5°C using the flask method.