4-Ethoxy-4'-ethyl-2,3-difluoro-1,1'-biphenyl

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

GLP compliance:

no

Type of method:

Laser scattering/diffraction

Type of particle tested:

agglomerate

Type of distribution:

volumetric distribution

Mass median aerodynamic diameter:

ca. 309.6 µm

Remarks on result:

other:

Remarks:

St. dev. not determined

Key result

Percentile:

D10

Mean:

ca. 120.6 µm

Remarks on result:

other: St. dev. not determined

Key result

Percentile:

D50

Mean:

ca. 309.6 µm

Remarks on result:

other: st. dev. not determined.

Key result

Percentile:

D90

Mean:

ca. 783.2 µm

Remarks on result:

other: st. dev. not determined.

The test item consisted of rod-shaped transparent particles.

The test item was tested as a liquid dispersion in demineralized water (with 1 % detergent). This homogenised dispersion was fed to the sample unit. Subsequently the diluted dispersion was pumped to the optical system. After passing the spectrometer the sample was pumped back into the small volume sample dispersion unit.

After adjusting the laser, measuring the background (demineralized water with 1 % detergent) and adjusting the correct particle concentration (obscuration) the measurement was started. The control software automatically performed three measurements. The average of these three measurements was given as result. Two test series of three measurements each were performed. The measurement time was 12 s.

The particle size distributions determined in the first and second test series are shown in Figure 1 (page 8) and Figure 2 (page 9), respectively. For each test series fractions (left axis of the ordinate) and the siftings (right axis of the ordinate) are presented in percent by volume as a function of the particle size. Median values were calculated from unrounded values.

 

The median particle size L50(D (v, 0.5): 50 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1sttest series: L50= 312.6 μm

2ndtest series: L50=306.7 μm

The average of the median particle size L50was: L50= 309.6 μm

 

The particle size L10 (D (v, 0.1 ): 10 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1sttest series: L10= 121.7 μm

2ndtest series: L10= 119.4 μm

The average of the particle size L10was: L10= 120.6 μm

 

The particle size L90(D (v, 0.9): 90 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1sttest series: L90= 783.3 μm

2ndtest series: L90= 783.1 μm

The average of the particle size L90was: L90= 783.2 μm

 

The particle size distribution showed a maximum at approximately 300 µm and a shoulder at approximately 30 µm.

Conclusions:

The median particle sizes D10, D50 and D90 were determined to be 120.6 μm, 309.6 μm and 783.2 μm, respectively.

Executive summary:

The determination of the particle size distribution by laser diffraction of the test item was performed according to the European Commission Regulation (EC) No.440/2008 by laser diffraction. The median particle sizes D10, D50 and D90 of the test item deduced from the particle size distributions were 120.6 μm, 309.6 μm and 783.2 μm, respectively.

Description of key information

The median particle sizes D10, D50 and D90 were determined to be 120.6 μm, 309.6 μm and 783.2 μm, respectively.

Additional information

The determination of the particle size distribution by laser diffraction of the test item was performed according to the European Commission Regulation (EC) No.440/2008 by laser diffraction. The median particle size L50of the test item deduced from the particle size distributions was 309.6 µm.