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EC number: - | CAS number: -
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 September 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
- Version / remarks:
- 1981
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Version / remarks:
- 2009
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)
- Version / remarks:
- 1996
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- 3-(aminocarbonyl)-1-ß-D-ribofuranosyl-pyridinium bromide
- Cas Number:
- 78687-39-5
- Molecular formula:
- C11H15BrN2O5
- IUPAC Name:
- 3-(aminocarbonyl)-1-ß-D-ribofuranosyl-pyridinium bromide
- Reference substance name:
- Nicotinamide
- EC Number:
- 202-713-4
- EC Name:
- Nicotinamide
- Cas Number:
- 98-92-0
- Molecular formula:
- C6H6N2O
- IUPAC Name:
- nicotinamide
- Reference substance name:
- Methanol
- EC Number:
- 200-659-6
- EC Name:
- Methanol
- Cas Number:
- 67-56-1
- Molecular formula:
- CH4O
- IUPAC Name:
- methanol
- Reference substance name:
- Ethyl acetate
- EC Number:
- 205-500-4
- EC Name:
- Ethyl acetate
- Cas Number:
- 141-78-6
- Molecular formula:
- C4H8O2
- IUPAC Name:
- ethyl acetate
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- Oxidane
- Reference substance name:
- inorganic salts by sulphated ash
- IUPAC Name:
- inorganic salts by sulphated ash
- Reference substance name:
- Bromic acid
- EC Number:
- 232-158-3
- EC Name:
- Bromic acid
- Cas Number:
- 7789-31-3
- Molecular formula:
- BrHO3
- IUPAC Name:
- bromic acid
- Reference substance name:
- Unknown impurities.
- Molecular formula:
- Not available as unknown impurities.
- IUPAC Name:
- Unknown impurities.
- Test material form:
- solid
- Details on test material:
- Batch / Lot No. 1000146/01
Constituent 1
impurity 1
impurity 2
impurity 3
impurity 4
impurity 5
impurity 6
impurity 7
- Specific details on test material used for the study:
- Batch No.: 1000146/01
Storage Conditions: Freezer (approx. -15 °C)
Since the test item contains no lager particles, sieving < 2000 µm was not necessary and the test item was used as delivered.
Results and discussion
Particle sizeopen allclose all
- Key result
- Percentile:
- D10
- Mean:
- 1.2 µm
- St. dev.:
- 0.01
- Remarks on result:
- other: Average result calculated from the results of two test series
- Key result
- Percentile:
- D50
- Mean:
- 4.8 µm
- St. dev.:
- 0.03
- Remarks on result:
- other: Average result calculated from the results of two test series
- Key result
- Percentile:
- D90
- Mean:
- 22.7 µm
- St. dev.:
- 1.53
- Remarks on result:
- other: Average result calculated from the results of two test series
Any other information on results incl. tables
LIGHT MICROSCOPY
At 5x and 20x magnifications small agglomerates can be observed, which can be easily destroyed by mechanical force.
PARTICLE SIZE DISTRIBUTION
Two test series of 3 measurements each were performed with the test item.
Test series 1:
| Percentile | Particle size (µm) | Standard deviation |
| D10 | 1.2 | 0.02 |
| D50 | 4.8 | 0.04 |
| D90 | 24.7 | 3.12 |
Test series 2:
| Percentile | Particle size (µm) | Standard deviation |
| D10 | 1.2 | 0.01 |
| D50 | 4.7 | 0.07 |
| D90 | 20.7 | 2.28 |
Applicant's summary and conclusion
- Conclusions:
- The test item Nicotinamide-beta-D-riboside bromide (CAS no. 78687-39-5) has a median particle size D50 = 4.8 µm, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981), ISO 13320 (2009) and EPA OCSPP Guideline OPPTS 830.7520 (1996).
- Executive summary:
The test item Nicotinamide-beta-D-riboside bromide (CAS no.78687-39-5) has a median particle size of D50 = 4.8 µm, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981), ISO 13320 (2009) and EPA OCSPP Guideline 830.7520 (1996).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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