Registration Dossier
Registration Dossier
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EC number: 425-030-5 | CAS number: 159939-85-2
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD guideline for Testing of Chemicals, Section 4, No. 474, adopted May 26, 1983, "Micronucleus test" EEC directive 92/69, L383, Annexe V, B12, Dated December 29, 1992.
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- deionised water
- No. of animals per sex per dose:
- Male: 50 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 170 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 500 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 500 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Female: 50 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 170 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 500 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 500 mg/kg; No. of animals: 5; Sacrifice times: 48 hours
Results and discussion
Test results
- Toxicity:
- yes
- Remarks:
- Doses producing toxicity: 2000 mg/kg, 1000 mg/kg, 500 mg/kg
- Additional information on results:
- Observations:
At 500 mg:kg bwt, the following toxic reactions were
observed : reduction of spontaneous activity, eyelid closure
and apathy.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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