Registration Dossier
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EC number: 814-560-6 | CAS number: 1429755-57-6
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental start date 22 January 2020 Experimental completion date 11 May 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- E-N'-{2-cyano-4-[3-(2-hydroxy-1,1-dimethylethyl)-thioureido]-phenyl}-N,N-dimethylformamidine
- Cas Number:
- 1429755-57-6
- Molecular formula:
- C15H12N5OS
- IUPAC Name:
- E-N'-{2-cyano-4-[3-(2-hydroxy-1,1-dimethylethyl)-thioureido]-phenyl}-N,N-dimethylformamidine
Constituent 1
- Specific details on test material used for the study:
- Identification: SPS 5290 Stage 3
Batch: 80034242B
Purity: 99.5%
Physical State/Appearance Yellow powder
Expiry Date: 05 July 2020
Storage Conditions: Room temperature (15 to 25°C)
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 0.13
- Temp.:
- 25 °C
- pH:
- 7
- Details on results:
- A calibration plot of log10k’ versus log10Pow was constructed for the reference standards. The logarithm of the capacity factor for the test item was then calculated and the log10Pow value was determined by extrapolation.
The test item, SPS 5290 Stage 3, was thus determined to have a log10Pow value of 0.13 (equivalent to a Pow value of 1.4)
Applicant's summary and conclusion
- Conclusions:
- The test item, SPS 5290 Stage 3, was found to have a log10Pow value of 0.13.
- Executive summary:
The purpose of this study was to evaluate the partition coefficient of the test item, SPS 5290 Stage 3.
The study was conducted in accordance with accepted principles in order to meet the requirements of REACH Regulation (EU) No 1907/2006 of the European Parliament and of the Council, Commission Regulation (EC) No 440/2008 (as amended) of 30 May 2008 and the OECD Guidelines for Testing of Chemicals.
This study was conducted according to EC Method A.8 and OECD Method 117.
The test item, SPS 5290 Stage 3, was found to have a log10Pow value of 0.13.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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