Cyclohexanepropanol, 2,2,3,6-tetramethyl-.alpha.-propyl-

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

04-09-2019 to 19-02-2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study performed under GLP. All relevant validity criteria were met.

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

inspected: August 2018 ; signature: November 2018

Type of method:

effusion method: vapour pressure balance

Temp.:

25 °C

Vapour pressure:

0.034 Pa

Remarks on result:

other: Mean Vp (n=6): extrapolated from log Vp (Pa) vs. 1/T curve of 6 individual runs

Test no.:

#1

Temp.:

25 °C

Vapour pressure:

0.034 Pa

Test no.:

#2

Temp.:

25 °C

Vapour pressure:

0.034 Pa

Test no.:

#3

Temp.:

25 °C

Vapour pressure:

0.034 Pa

Test no.:

#4

Temp.:

25 °C

Vapour pressure:

0.034 Pa

Test no.:

#5

Temp.:

25 °C

Vapour pressure:

0.035 Pa

Test no.:

#6

Temp.:

25 °C

Vapour pressure:

0.034 Pa

Transition / decomposition:

no

Remarks on result:

other: The test item did not change in appearance under the conditions used in the determination

Table 1.0 – vapour pressure determination of the test item

Run	Log10 Vp (25°C)	Vp(25°C) [Pa]
4	-1.47	0.0338
5	-1.46	0.0344
6	-1.47	0.0342
7	-1.47	0.0337
8	-1.46	0.0347
9	-1.47	0.0337
Mean	-1.47	0.0341

 

The slope and intercept of the 6 individual runs for the plot of Log10 Vp (Pa) versus reciprocal of temperature (K) is recorded in the full study report. A total of 10 runs were completed for the main sequence. Runs 1 to 3 have not been utilised as the sample was still equilibrating; run 10 has not been utilised as the nature of the plot would require excessive point removal. With regard to equilibrium, this has been assessed to have been reached over runs 4 to 9 which were used to calculate the vapor pressure.

There was no evidence of decomposition during the course of the test (no change in appearance).

Conclusions:

The vapour pressure of the test item has been determined to be 0.0341 Pa at 25 °C.

Executive summary:

The vapour pressure was determined using EU Method A.4 guideline using the vapour pressure balance method under GLP. Measurements being made at several temperatures and linear regression analysis used to calculate the vapour pressure at 25°C. The temperature of the sample was controlled electronically. The mass and temperature readings were recorded automatically into a computer file. The difference in mass readings with the orifice covered and uncovered is proportional to the vapour pressure at the given oven temperature. Temperature and pressure readings were taken between 40 and 50°C. The vapour pressure of the test item was extrapolated from the vapour pressure curve (log10 Vp versus 1/T). The mean vapour pressure based on six runs was 0.0341 Pa at 25°C..

Description of key information

Vapour Pressure: 0.0341 Pa at 25 °C, EU Method A.4 – vapour pressure balance method, 2020

Key value for chemical safety assessment

Vapour pressure:

0.034 Pa

at the temperature of:

25 °C

Additional information

Key study : EU Method A.4, 2020 : The vapour pressure was determined using EU Method A.4 guideline using the vapour pressure balance method under GLP. Measurements being made at several temperatures and linear regression analysis used to calculate the vapour pressure at 25°C. The temperature of the sample was controlled electronically. The mass and temperature readings were recorded automatically into a computer file. The difference in mass readings with the orifice covered and uncovered is proportional to the vapour pressure at the given oven temperature. Temperature and pressure readings were taken between 40 and 50°C. The vapour pressure of the test item was extrapolated from the vapour pressure curve (log10 Vp versus 1/T). The mean vapour pressure based on six runs was 0.0341 Pa at 25°C.