Registration Dossier
Registration Dossier
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EC number: 848-720-1 | CAS number: 1616494-50-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 March 2020 - 03 April 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- N,N-Di-(2-Ethylhexyl)-amino Isostearamide
- EC Number:
- 848-720-1
- Cas Number:
- 1616494-50-8
- Molecular formula:
- C34H69NO
- IUPAC Name:
- N,N-Di-(2-Ethylhexyl)-amino Isostearamide
- Test material form:
- liquid
Constituent 1
In vitro test system
- Test system:
- human skin model
- Vehicle:
- unchanged (no vehicle)
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- 3 minute
- Value:
- ca. 92.7
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- 60 minute
- Value:
- ca. 98.1
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- In this study and under the experimental conditions reported:
The test item was considered to be non-corrosive to the skin. - Executive summary:
In this study and under the experimental conditions reported:
The test item was considered to be non-corrosive to the skin.
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