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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
(1E)-1-(2H-1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-one
EC Number:
604-446-2
Cas Number:
144850-45-3
Molecular formula:
C14H16O3
IUPAC Name:
(1E)-1-(2H-1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-one
Test material form:
solid: particulate/powder

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
yes
Remarks:
ultrapure water
Details on test solutions:
a special solubilization protocol was carried out before the experimentation according to OECD n°23 guidance document on aquatic toxicity testing of difficult subtances and mixtures

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
static
Water media type:
other: ultrapure water
Limit test:
no
Total exposure duration:
48 h

Test conditions

Test temperature:
between 18 and 22°C
pH:
range 6 - 9
Nominal and measured concentrations:
0.6 - 1.2 - 2.5 - 5 - 10 and 20 mg/L
Reference substance (positive control):
yes
Remarks:
K2Cr2O7

Results and discussion

Effect concentrationsopen allclose all
Key result
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
11.3 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
5.4 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Results with reference substance (positive control):
not precised

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The results obtained for Stiripentol Stade 1 are :
- EC50-24h = 11.3 mg/L
- EC50-48h = 5.4 mg/L
In regard to these results the test item can be classified in Category : Acute II.
Executive summary:

The acute toxicity on aquatic invertebrates was performed according the OECD 202 guideline.

The results obtained for Stiripentol Stade 1 are :

-  EC50-24h = 11.3 mg/L

- EC50-48h = 5.4 mg/L

In regard to these results the test item can be classified in Category : Acute II.