Registration Dossier
Registration Dossier
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EC number: 951-985-7 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental Phase: 14 June 2020 to 05 September 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. 2.45
- Remarks on result:
- other: The test was performed at approximately neutral pH. The HPLC column temperature was 30 °C.
- Type:
- Pow
- Partition coefficient:
- ca. 281
- Remarks on result:
- other: The test was performed at approximately neutral pH. The HPLC column temperature was 30 °C.
- Conclusions:
- The partition coefficient (n-octanol:water) of the test item has been determined to be 281, log10 Pow 2.45.
- Executive summary:
Introduction
The partition coefficient of the test item was determined using a method designed to be meet the requirements of the following guidelines:
- Method A.8 Partition Coefficient of Commission Regulation (EC) No. 440/2008 of 30 May 2008
- Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004
Method
The test system consisted of a high-performance liquid chromatograph with an appropriate detector. A reverse phase HPLC column with a very low percentage of polar groups was used and the mobile phase contained at least 25% aqueous phase.
The partition coefficent was determined by reference to a calibration curve plotted against reference standards.
Result and Conclusion
The partition coefficient (n-octanol:water) of the test item has been determined to be 281, log10 Pow 2.45.
Reference
The retention times, capacity factor and log10 Pow value determined for the sample are shown in the following table:
| Injection | Retention Time (mins) |
Capacity Factor (k') |
Log10 k' | Log10 Pow |
| 1 | 6.618 | 3.625 | 0.5593 | 2.45 |
| 2 | 6.613 | 3.621 | 0.5589 | 2.45 |
Mean log10 Pow: 2.45
Partition coefficient: 281
Description of key information
Partition coefficient data summary.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.45
Additional information
The partition coefficient (n-octanol:water) of the test item has been determined to be 281, log10 Pow 2.45.
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