Registration Dossier
Registration Dossier
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EC number: 201-161-1 | CAS number: 78-95-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2020-06-15 to 2020-07-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 33.9 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 5 000 g/L
- Incubation duration:
- >= 48 - <= 96 d
- Temp.:
- 20 °C
- pH:
- 1.4
- Conclusions:
- The water solubility of the test item was determined to be 33.9 g/L at 20 °C and pH 1.4.
- Executive summary:
The water solubility was determined according to Regulation (EC) No 440/2008, method A.6 and OECD Guideline No. 105, adopted on 27th July 1995 using the flask method with HPLC analysis. Three flasks were prepared with an amount of test item and water, and one flask only with water. After stirring and centrifugation the aqueous phases were measured by means of HPLC. The solution of each flask has been measured twice. The water solubility of the test item was determined to be 33.9 g/L at 20 °C and pH 1.4.
Reference
For the main test three flasks were prepared with an amount of test item and water, and one flask only with water. After stirring and centrifugation the aqueous phases were measured by means of HPLC. The solution of each flask has been measured twice. The results of these measurements are shown in the following table. The values represented in the table are rounded values. The calculation was carried out with the original not rounded values.
Table: Results of the flask method
Flask | 1a | 2a | 3a | 4a |
measured value [mg/L] | 1690.9 / 1708.0 | 1667.5 / 1663.0 | 1684.7 / 1763.8 | 0 / 0 |
aliquot of the flask [mL] | 0.05 | 0.05 | 0.05 | 0.05 |
total volume after 1st dilution [mL] | 1 | 1 | 1 | 1 |
water solubility [g/L]* | 33.8 / 34.2 | 33.4 / 33.3 | 33.7 / 35.3 | 0 / 0 |
average water solubility [g/L] | 34.0 | 33.3 | 34.5 | 0 |
mean value of the water solubility [g/L] | 33.9 | 0 | ||
standard deviation [g/L] | 0.6 | -- | ||
relative standard deviation [%] | 1.75 | -- | ||
* Under consideration of the dilution factor 20
Description of key information
The water solubility of the test item was determined to be 33.9 g/L at 20 °C and pH 1.4 (reference 4.8-1).
Key value for chemical safety assessment
- Water solubility:
- 33.9 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility was determined according to Regulation (EC) No 440/2008, method A.6 and OECD Guideline No. 105, adopted on 27th July 1995 using the flask method with HPLC analysis. Three flasks were prepared with an amount of test item and water, and one flask only with water. After stirring and centrifugation the aqueous phases were measured by means of HPLC. The solution of each flask has been measured twice. The water solubility of the test item was determined to be 33.9 g/L at 20 °C and pH 1.4.
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