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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1973
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Two rabbits were exposed to 2 g/kg of test substance dermally. Not enough test substance was available to expose additional animals.
GLP compliance:
no
Test type:
fixed dose procedure
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
7-hydroxycitronellal
EC Number:
203-518-7
EC Name:
7-hydroxycitronellal
Cas Number:
107-75-5
Molecular formula:
C10H20O2
IUPAC Name:
7-hydroxy-3,7-dimethyloctanal

Test animals

Species:
rabbit

Administration / exposure

Doses:
- 2000 mg/kg bw
No. of animals per sex per dose:
2
Control animals:
not required
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
None
Clinical signs:
other: None

Any other information on results incl. tables

Mortality


 

































































DayMortality
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Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The dermal LD50 for rabbits is > 2000 mg/kg bw.
Executive summary:

The acute dermal toxicity for the test substance was determined by exposing two rabbits to 2000 mg/kg bw of test substance.  Due to limited amount of test substance only two animals were dosed.  The animals were then monitored for 14 days for clinical signs and mortality.  Both animals survived.  The dermal LD50 is therefore >2000 mg/kg bw.