1H-Isoindole-1,3(2H)-dione, 2-[(6,11-dihydro-5H-dibenz[b,e]azepin-6-yl)methyl]-

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

(Q)SAR

Adequacy of study:

disregarded due to major methodological deficiencies

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

Documentation about the justification is provided in attachment (See Supporting information). The reliability assessment of the prediction is shown in the attached document as well (QPRF). QSAR model reporting format is shown in the QMRF file attached.

Data source

Reference

Reference Type:

other: QSAR model

Title:

VEGA in silico platform

Bibliographic source:

Fathead Minnow LC50 96h (EPA) 1.0.8

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.

Test material

Test material information

Details on test material:

The SMILES included in the reference substance linked in Section 1 (General information) was used as model input.

Specific details on test material used for the study:

C1C2=CC=CC=C2C(NC3=CC=CC=C31)CN4C(=O)C5=CC=CC=C5C4=O

Results and discussion

Effect concentrations

Dose descriptor:

LC50

Effect conc.:

ca. 0.277 mg/L

Conc. based on:

test mat.

Any other information on results incl. tables

Sublethal observations / clinical signs:

The prediction was deemed not  to be reliable on the basis of the parameters listed above. The molecule does not fall into the applicability domain of the model.

Applicant's summary and conclusion

Conclusions:

The Fathead Minnow LC50 of the substance was predicted to be 0.2765 mg/L.