Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: -
CAS number: -
A toxicokinetic assessment was performed based on the available data of
dilithium tetraborate. Based on the physical/chemical properties of
dilithium tetraborate, absorption factors for this substance are derived
to be 100% (oral), 100% (inhalation of aqueous aerosols) and 0.5 %
(dermal absorption from aqueous solutions) for risk assessment purposes.
The bioaccumulation potential is expected to be low.
A toxicokinetic assessment was performed based on data available for dilithium tetraborate as well as for calcium metaborate. Based on the physical/chemical properties of dilithium tetraborate as well as for calcium metaborate, absorption factors for this substance are derived to be 100% (oral), 100% (inhalation of aqueous aerosols) and 0.5% (dermal absorption from aqueous solutions) for risk assessment purposes. The bioaccumulation potential is expected to be low
As Reaction products of boric acid and calcium dihydroxide and lithium hydroxide has similar physicochemical properties ie. low vapour pressure and soluble in water then it is expected that the toxicokinetics assessment would be similar for Reaction products of boric acid and calcium dihydroxide and lithium hydroxide especially since all absorption factors derived were based on evidence for boric compounds such as boric acid. The inorganic borates, will be converted to boric acid at physiological pH in the aqueous layer on the surfaces of the mucosa. Boric acid is known to be readily taken up from the gastrointestinal tract in rats and humans, as demonstrated by experimental evidence in both human and animal studies, where more than 90% of the administered dose of borate was excreted as boric acid.
The target UVCB substance has a higher precursor molar ratio for lithium hydroxide than for calcium hydroxide, and therefore the precautionary principle should be applied and read across from dilithium tetraborate where relevant to consider the worst case.
Sufficient evidence therefore exists to propose the same absorption factors for the toxicokinetics assessment. Read-across to dilithium tetraborate is proposed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again