Registration Dossier
Registration Dossier
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EC number: 606-682-1 | CAS number: 2098-65-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February -March 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- study was conducted prior to implementation of OECD TG 423
- Deviations:
- yes
- Remarks:
- two different sexes
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 17-Hydroxy-1 alpha,2 alpha-methylene-4,6-pregnadiene-3,20-dione
- EC Number:
- 606-682-1
- Cas Number:
- 2098-65-9
- Molecular formula:
- C22 H28 O3
- IUPAC Name:
- 17-Hydroxy-1 alpha,2 alpha-methylene-4,6-pregnadiene-3,20-dione
- Test material form:
- solid: bulk
- Remarks:
- ???
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
No deaths occurred as well as no deviations in weight development. Moreover, application of 2000 mg/kg was tolerated without any compound-related clinical or macroscopic pathological signs.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- the test item is of low acute oral toxicity
- Executive summary:
The single oral administration of the test substance (ZK 12126) to male and female rats at a dose of 2000 mg/kg was tolerated without any mortality and compound-related clinical or macroscopic pathological signs. Therefore, the acute oral toxicity of 1,2 -Methylene-4,6-dien in rats is above 2000 mg/kg body weight.
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