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EC number: 484-350-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Ames test:
In an ames test according to OECD and EC test guidelines, Radiagreen RA was tested in the Salmonella typhimurium reverse mutation assay with four histidine requiring strains (TA1535, TA1537, TA98 and TA100) and in the Escherichia coli reverse mutation assay with a tryptophan requiring strain (WP2uvrA) in presence and absence of S9 mix. The substance was tested up to 3330 microgram/plate in the absence and presence of S9 mix, and showed precipitation at the highest dose and in addition toxicity was seen in some of the strains. Radiagreen RA did not induce a significant increase in the number of revertant colonies in all strains tested in the absence and presence of S9 metabolic activation. Therefore, the substance is considered to be not mutagenic in this study.
Chromosome aberration test:
In a chromosome aberration study according to OECD and EC test guidelines, Radiagreen RA was tested in cultured peripheral human lymphocytes in the presence and absence of metabolic activation for chromosome aberrations and clastogenicity. Radiagreen was tested up to 600 microgram/ml showing toxicity and/or precipitation under the different test conditions. The substance did not induce a statistically significant or biologically relevant increase in the number of cells with chromosome aberrations in the absence and presence of S9 mix. No effects on polyploid cells and cells with endoreduplicated chromosomes were observed. Therefore, the substance is considered not to disturb the mitotic processes and cell cycle progression, it does not induce numerical chromosome aberrations and it is not clastogenic.
MLA test:
In a mammalian cell gene mutation test with L5178Y mouse lymphoma cells according to OECD and EC test guideline, Radia 7838 was tested on the induction of forward mutations at the TK locus in L5178Y mouse lymphoma cells in the presence and absence of metabolic activation. Radia 7838 was tested up to 1000 microgram/ml showing precipitation and/or cytotoxicity. The substance did not induce a significant increase in the mutation frequency in the presence and absence of S9 -mix. Therefore, Radia 7838 is considered to be not mutagenic.
Short description of key information:
The Ames study was performed according to OECD Guideline 471 and GLP principles. The chromosome aberration study was performed according to OECD Guideline 473 and GLP principles. The TK mutation test was performed according to OECD Guideline 476 and GLP principles. All tests were considered negative with regard to genotoxicity.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
It can be concluded that Radia 7838 is not considered mutagenic/clastogenic according to CLP Regulation (EC) No. 1272/2008.
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