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EC number: 470-090-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
CAS No.:388606-32-4
Batch No.: YH00701
Chemical name: 1-[(3-Aminopropyl)dimethylsilyl]-2,2dimethyl-1-aza-2-silacyc1opentan
Purpose: industrial chemical
Colour: colourless to yellowish
Physical state: liquid
Storage: at room temperature, protected from light and humidity
Safety precautions: Routine hygienic procedures were sufficient
to assure personnel health and safety
Test animals
- Species:
- rat
- Strain:
- other: HsdRccHan:WIST
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- HsdRccHan : WIST rats (Full-Barrier), Sex: male and female. Body weight at the commencement of the study: male 240 - 258 g and female 213 - 219 g. 5 male and 5 female animals were used. The animals were derived from a controlled full barrier maintained breeding system (SPF).
Source: Harlan Winkelmann GmbH, D-33178 Borchen.
The animals were barrier maintained (semi-barrier) in an air conditioned room
Temperature: 22 ± 3 °C
Rel. humidity: 55 ± 10%
Artificial light, sequence being 12 hours light, 12 hours dark
Air change: 10 x / hour
Feeding ad libitum, ssniffR/M-H, 10 mm V1534-000, complete diet for rats/mice - maintenance, totally-pathogen-free (TPF)
Free access to tap water (drinking water, municipal residue control, microbiol. controlled peri-odically)
The animals were kept in Macrolon cages on Lignocel bedding.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The animals were marked for individual identification by tail painting. Approximately 24 hours before the test, fur was removed from the dorsal area of the trunk by clipping. Not less than 10% of the body surface was cleared for the application. Prior to the application a detailed clinical observation was made of all animals. The test item was applied in a single dose by applying uni-formly over an area which was approx. 10% of the total body surface. Test item was held in con-tact with the skin with a gauze-dressing and non-irritating tape and was fixed with an additional dressing in a suitable manner.
- Duration of exposure:
- 24 h
- Doses:
- The test item was applied at a single dose (2000 mg/kg bw) by applying uniformly over an area which was approx. 10% of the total body surface.
- No. of animals per sex per dose:
- 5 female, 5 male
- Control animals:
- no
- Details on study design:
- A careful clinical examination was made at least twice on the day of dosing and once a day thereafter. Cageside observations included changes in the skin and fur, eyes and mucous membranes. Also respiratory, circulatory, autonomic and central nervous systems and somatomotor activity and behaviour pattern were examined. Particular attention was directed to observations of tremor, convulsions, salivation, diarrhoea, lethargy, sleep and coma.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- < 2 000 mg/kg bw
- Remarks on result:
- other: Exact LD50 could not be detected since all animals died during the exposition.
- Mortality:
- all animals died
- Clinical signs:
- All test animals: Complete destruction of skin, subcutanous tissue as well as musculature and compound-related mortality within 24 hours after
application. Cause of death was assumed to be the deep destruction over a large area (10% of the body surface). - Body weight:
- not detected due to death of the animals
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Considering the reported data of this dermal toxicity test it can be stated that the test item causes severe acute dermal toxic characteristics in a preliminary test.
- Executive summary:
The test item 1-[(3-Aminopropyl)dimethylsilyl]-2,2dimethyl-1-aza-2-silacyclopentan was administered topically at a single dose (2000 mg/kg bw) by applying uniformly over an area which was approx. 10% of the total body surface according to OECD guideline 402. 5 male animals (HsdRccHan : WIST rats) as well as 5 female animals (HsdRccHan : WIST rats) were used. The test item was held in contact by an occlusive dressing with the skin throughout a 24-hour period. The occlusive dressing consisted of a gauze dressing and non-irritating tape and was fixed with an additional dressing in a suitable manner. A careful clinical examination was made at least twice on the day of dosing and once a day thereafter. Necropsy was carried out to record gross
pathological changes. All test animals showed complete destruction of skin, subcutanous tissue as well as musculature and compound-related mortality within 24 hours after application. Cause of death was assumed to be the deep destruction over a large area (10% of the body surface) of the skin. The radical destruction was reconfirmed at necropsy. According to OECD 402 dosing test substances in a way to be known to cause marked pain and distress due to corrosive or irritating properties need not be carried out. Considering the reported data of this dermal toxicity test it can be stated that the test item causes severe acute dermal toxic characteristics in a preliminary test. For animal welfare reasons concerning the above reported results and in accordance with the sponsor no further animals were treated.
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