Registration Dossier
Registration Dossier
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EC number: 219-754-9 | CAS number: 2524-03-0
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 2010
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- O,O-dimethyl phosphorochloridothioate
- EC Number:
- 219-754-9
- EC Name:
- O,O-dimethyl phosphorochloridothioate
- Cas Number:
- 2524-03-0
- Molecular formula:
- C2H6ClO2PS
- IUPAC Name:
- O,O-dimethyl chlorophosphonothioate
- Details on test material:
- - Name of test material (as cited in study report): Phosphorochloridothioic acid, O,O-dimethyl ester
- Physical state: liquid
- Lot/batch No.: 2010021502
- Storage condition of test material:app. 4°C in the dark
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 10, 25, 50 % v/v
- No. of animals per dose:
- 4
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: See table.
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: See table.
Any other information on results incl. tables
| Concentration (% v/v) in acetone/olive oil 4:1 | Stimulation Index | Result | dpm | dpm/node |
| 10 | 13.20 | Positive | 75321.91 | 9415.24 |
| 25 | 15.70 | Positive | 89551.04 | 11193.88 |
| 50 | 17.51 | Positive | 99896.66 | 12487.08 |
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Conclusions:
- Based on expert judgement, this study is considered as false positive due to the acid effect from the substance. Therefore, the conclusion will be that the substance is not sensitising.
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